Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models

Kumar, A., Shahul, A. K., & Bhalla, U. S. (2025). Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models. Journal of Neurophysiology. doi:10.1152/jn.00617.2024

Requirements

1. A debian based linux system such as Ubuntu or Linux mint. All codes will work on WSL in Windows too. Other systems were not tested.
2. python3.8-3.12. Not tested on other python versions.
3. pymoose (must be built from source by following the instructions)
4. NEURON with python support

Requirements to regenerate data

5. goMultiprocessing
6. brute_curvefit

Folder descriptions

• expdata - Contains raw experimental data
• Fig1-9, SuppFigS1 - Contains scripts to generate paper figures
• FigAbstract - Abstract figure
• helperScripts - Contains script to generate some data and utility scripts
• Kinetics - Contains files that describe ion channel kinetics used in this study