In WPF DataGrid (SfDataGrid), you can show tooltip for the disabled GridCell by writing style and enabling ToolTipService.ShowOnDisabled.
<syncfusion:SfDataGrid x:Name="dataGrid"
AutoGenerateColumns="False"
ItemsSource="{Binding Path=OrdersDetails}"
ColumnSizer="Auto"
ShowToolTip="true">
<syncfusion:SfDataGrid.Columns>
<syncfusion:GridTextColumn MappingName="OrderID" />
<syncfusion:GridTextColumn MappingName="CustomerID" />
<syncfusion:GridTextColumn MappingName="ShipCountry" >
<syncfusion:GridTextColumn.CellStyle>
<Style TargetType="syncfusion:GridCell" >
<Setter Property="IsEnabled" Value="False" />
<Setter Property="ToolTip" >
<Setter.Value>
<TextBlock Text="{Binding ShipCountry}"
Foreground="Red"
ToolTipService.IsEnabled="True"
ToolTipService.ShowOnDisabled="True"/>
</Setter.Value>
</Setter>
<Setter Property="ToolTipService.IsEnabled" Value="True" />
<Setter Property="ToolTipService.ShowOnDisabled" Value="True" />
</Style>
</syncfusion:GridTextColumn.CellStyle>
</syncfusion:GridTextColumn>
<syncfusion:GridTextColumn MappingName="Freight" />
<syncfusion:GridCheckBoxColumn HeaderText="Closed"
MappingName="IsClosed" />
</syncfusion:SfDataGrid.Columns>
</syncfusion:SfDataGrid>
Take a moment to peruse the WPF DataGrid - ToolTip documentation, to learn more about tooltip with examples.