diff --git a/targets/TARGET_NUVOTON/USBEndpoints_Nuvoton.cpp b/targets/TARGET_NUVOTON/USBEndpoints_Nuvoton.cpp
index 26b04130c80..d0671cdc58a 100644
--- a/targets/TARGET_NUVOTON/USBEndpoints_Nuvoton.cpp
+++ b/targets/TARGET_NUVOTON/USBEndpoints_Nuvoton.cpp
@@ -37,6 +37,7 @@ static USBPhyHw *instance;
 #define MBED_CONF_TARGET_USB_DEVICE_HSUSBD 1  /* USB 2.0 Only */
 #endif
 
+#if defined(DEVICE_USBDEVICE) && (DEVICE_USBDEVICE == 1)
 
 extern "C" void USBD_IRQHandler(void);
 
@@ -2374,3 +2375,5 @@ extern "C" void USBD_IRQHandler(void)
 }
 
 #endif
+
+#endif
\ No newline at end of file